Acute Lymphoblastic Leukemia Complicated by Acute Severe Asthma - A Rare Finding: A Case Report

Marcellinus Uchechukwu Nwagu


Introduction : The leukaemias are a group of disorders characterized by the accumulation of
malignant white cells in the bone marrow and blood. These abnormal cells cause symptoms
because of bone marrow failure and infiltration of organs; but acute severe asthma has not been
reported as one of the manifestations/complications of acute lymphoblastic leukemia.
Objective: The aim of this paper is to briefly review the literature on acute lymphoblastic leukemia
and its clinicopathologic relationship with asthma. A case of Acute Lymphoid leukemia being
complicated by acute severe asthma is also reported.
Method/Result: I present a 36-year old male welder who came to the hospital with anaemic heart
failure, leucocytosis and thrombocytopenia. Final diagnosis of acute lymphoblastic leukemia was
made following bone marrow aspiration cytology and was subsequently commenced on
chemotherapy. After successful Induction and Consolidation therapy, the patient had Acute
Severe Asthmatic attack during the maintenance therapy and subsequently died in the hospital.
Conclusion: Acute Lymphoblastic Leukemia can be complicated by acute severe asthma. Early
diagnosis and use of genuine cytotoxic drugs will go a long way to ameliorate the complications of
Acute gave variable results. Local injections with lidocaine were also successful.
Refractory cases had surgical decompression.
Conclusion: Entrapment neuropathies were common conditions prevented by early
identification and treatment.


Acute Lymphoblastic Leukemia Acute Severe Asthma

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