African Journal of Tropical Medicine and Biomedical Research <div class="page" title="Page 2"> <div class="layoutArea"> <div class="column"> <p>The African Journal of Tropical Medicine and Biomedical Research is a multidisciplinary and international journal published by the College of Health Sciences, Delta State University of Abraka, Nigeria.</p> <div class="page" title="Page 2"> <div class="layoutArea"> <div class="column"> <p>It provides a forum for Authors working in Africa to share their research findings on all aspects of Tropical Medicine and Biomedical Sciences and to disseminate innovative, relevant and useful information on tropical medicine and biomedical sciences throughout the continent... <a title="About the Journal" href="" target="_blank" rel="noopener">Continue Reading.</a></p> <p><strong><br /><a title="Authors Guideline" href="" target="_blank" rel="noopener">Instruction for Authors</a> </strong>| <strong><a title="Current Issue" href="" target="_blank" rel="noopener">Current Issue</a> | <a title="Past Issue" href="" target="_blank" rel="noopener">Past Issue</a> </strong>| <strong><a title="contact" href="">Contact/Support</a> </strong></p> </div> </div> </div> </div> </div> </div> College of Health Sciences, Delta State University, Abraka, Nigeria en-US African Journal of Tropical Medicine and Biomedical Research 2141-6397 <p>The data collected from registered and non-registered users of this journal falls within the scope of the standard functioning of peer-reviewed journals. It includes information that makes communication possible for the editorial process; it is used to informs readers about the authorship and editing of content; it enables collecting aggregated data on readership behaviors, as well as tracking geopolitical and social elements of scholarly communication.</p> <p>This journal’s editorial team uses this data to guide its work in publishing and improving this journal. Data that will assist in developing this publishing platform may be shared with its developer <a href="">Public Knowledge Project</a> in an anonymized and aggregated form, with appropriate exceptions such as article metrics. The data will not be sold by this journal or PKP nor will it be used for purposes other than those stated here. The authors published in this journal are responsible for the human subject data that figures in the research reported here.</p> <p>Those involved in editing this journal seek to be compliant with industry standards for data privacy, including the European Union’s General Data Protection Regulation (<a href="">GDPR</a>) provision for “<a href="">data subject rights</a>” that include (a) breach notification; (b) right of access; (c) the right to be forgotten; (d) data portability; and (e) privacy by design. The GDPR also allows for the recognition of “the public interest in the availability of the data,” which has a particular saliency for those involved in maintaining, with the greatest integrity possible, the public record of scholarly publishing.</p> Hyperglycemic emergencies in a tertiary health facility <p>Abstract<br /><strong>Aim</strong>: To assess the clinical presentations and predictors of mortality of hyperglycemic emergencies (HE) <br />in persons with diabetes mellitus (DM) presenting in a tertiary health facility in Nigeria.</p> <p><strong>Methods</strong>: This was a two-year retrospective review of hospital records of persons with DM in a tertiary <br />hospital in Nigeria. We retrieved data on person’s demographics, clinical and laboratory characteristics <br />into Microsoft Excel and analyzed with STATA version 14. </p> <p><strong>Results</strong>: A total of 195 (42.4%) out of 460 persons admitted with DM fulfilled the eligibility criteria. <br />Diabetic ketoacidosis (DKA) was present in 42.6%, mixed hyperglycemic emergency (MHE) in 34.9% <br />and hyperglycemic hyperosmolar state (HHS) in 22.5%. Mortality in HE was 8.7%. The common clinical <br />presentation were: osmotic symptoms (71.3%), tachypnoea (46.7%), tachycardia (42.6%). Elevated anion <br />gap (89.2%) and anemia (80.5%) were the common laboratory findings. Infections (86.7%), noncompliance (79.5%) and newly diagnosed DM were the common precipitants of HE. Significant <br />predictors of mortality were: duration of DM between 5-9 years, Glasgow Coma Scale (GCS) &lt; 8, <br />hypotension, and hypokalemia.</p> <p><strong>Conclusion</strong>: HE is still a common cause of hospitalization and mortality in persons with DM; and <br />features such osmotic symptoms, tachypnea and high anion gap metabolic acidosis should alert the <br />clinician.</p> Joseph Ovosi Beatrice Ohunene Bello-ovosi Isa Kweumpo Bansi Copyright (c) 2022 African Journal of Tropical Medicine and Biomedical Research 2022-01-01 2022-01-01 5 2 6 23 Assessment Of Haematological And Antioxidants Changes In Male Albino Wistar Rats Treated With Tramadol <p><strong>Abstract</strong><br /><strong>Introduction</strong><br />Illicit drug use disorders are a major public health burden that contributes significantly to the global burden of disease and tramadol is one of the most common illicit psychoactive substances being abused especially amongst the young adults. This research aims to assess the haematological and antioxidants activities of male wistar rats treated with tramadol. </p> <p><strong>Materials and Methods</strong><br />Thirty adult male Wistar rats weighing 120-180 g were selected for the study and was randomized into 6 groups. Group 1 was not treated within the period of the study before sacrificing, Group 2 to 5 received 30 mg/kg body weight of tramadol for 7, 14, 21 and 42 days respectively while treatment for group 6 was withdrawn for 3 weeks after 21 days treatment period before sacrificing. The animal's Brain, Liver, kidney and Testis were excised for biochemical analysis. Generated data were analyzed using SPSS package and results expressed as mean ± SEM. </p> <p><strong>Results</strong><br />Results obtained showed significant decrease in the haemtololgical parameters as well as in the WBC count, Catalase, SOD and Glutathione activities in the chronic tramadol-treated rats when compared to the normal control at p&lt;0.05. This study also revealed that chronic tramadol use increases the level ofMDA significantly when compared with the non-treated group. </p> <p><strong>Conclusion</strong><br />Tramadol consumption lowers RBC count, haemoglobin level, PCV, platelet count, WBC count, CAT, SOD, and GSH activities while significantly raising MDA levels. Therefore tramadol should only be used under medical supervision and only on prescription, avoiding indiscriminate and long-term.</p> Nduka Richard Ossai Emeka Anthony Ojieh Nwogueze Bartholomew Chukwuebuka Copyright (c) 2022 African Journal of Tropical Medicine and Biomedical Research 2022-01-01 2022-01-01 5 2 30 42 Intensity of Urinary Schistosomiasis and Prevalence of Urinary Tract Pathology Among Primary School Pupils in Delta State, South-south, Nigeria <p class="p1"><strong>Abstract</strong><br /><strong>Background</strong>: The urinary tract pathology (UTP) of urinary schistosomiasis is a common complication of the infection caused by inflammatory reactions mainly against the deposited egg antigens around the urinary tract and it is a disease of major public health importance.</p> <p class="p1"><strong>Objective</strong>: The aim of this study was to determine the correlation between the intensity of urinary schistosomiasis and the prevalence of its UTP among primary school pupils in Ndokwa-East Local Government Area (NELGA) of Delta State, South-south Nigeria.</p> <p class="p1"><strong>Method</strong>: This study was a cross sectional descriptive study of primary school children aged 5-15 years in Ndokwa-East Local Government Area (NELGA) of Delta State. Urine microscopy was used to identify infected primary school pupils. The intensity of infection was classified using egg count according to World Health Organization (WHO) standard, after which they participated in an ultrasound examination, using WHO guideline for schistosomiasis morbidity.</p> <p class="p1"><strong>Result</strong>: Among the infected subjects, 87.5% of those with severe infection had bladder wall pathology, while 71.4% of those with mild infection had bladder wall pathology (FET, p-value = 0.613). Additionally, 12.5% of those with severe infection as against 7.1% of those with mild infection had hydroureter (FET, p-value = 1.000), while 37.5% of those with severe infection as against 42.9% of those with mild infection had hydronephrosis (FET, p-value = 1.000).</p> <p class="p1"><strong>Conclusion</strong>: The prevalence and severity of UTP in this study had no significant relationship with the intensity of infection.</p> Nkemjika Mbagwu Ezeonwu Uzomavin Agabi JO Okolo Selina Copyright (c) 2022 African Journal of Tropical Medicine and Biomedical Research 2022-01-01 2022-01-01 5 2 24 29