Plasma electrolytes, osmolality and lipid profile in patients with acute stroke in a tertiary hospital in South-South, Nigeria.
DOI:
https://doi.org/10.4314/Keywords:
Acute Stroke, Plasma Electrolytes, Lipid profileAbstract
Introduction: Stroke or cerebrovascular accident is a leading cause of morbidity and mortality worldwide. Electrolyte imbalances and dyslipidemia cause poor patients' treatment outcomes.
Aim of the study was to evaluate Plasma electrolytes, osmolality and lipid profile in stroke patients.
Materials and Method: This was a descriptive cross-sectional study conducted between May 2022 to October 2022, on 144 stroke patients seen in the University of Benin Teaching Hospital. Serum electrolytes, Osmolality and lipid profile were assayed. Statistical analysis was done using SPSS version 22. Level of significance established at p ≤0.05
Result: 69.5% of the subjects had ischemic stroke, 30.5% had hemorrhagic stroke. 45.1% of the subjects had hyponatremia and hypo-osmolality, 49% had hypokalaemia, 21.5% had metabolic acidosis and 6% hypochloraemia. Majority of the subjects (98%-99.3%) had normal lipid profile. No statistically significant difference between the electrolyte results of both ischemic and hemorrhagic stroke.
Conclusion: Electrolyte derangements are common in patients with stroke. Hypokalaemia was the commonest observed, closely followed by hyponatremia and hypo-osmolality in this study. Electrolyte derangements in stroke patients should be promptly corrected and plasma levels monitored to reduce morbidity and mortality.
References
Donker ES Stroke in the 21 century; A Snap shot of the burden, Epidermiology, and Quality of life. Stroke Res Treat 2018
Wahab KW. The Burden of Stroke in Nigeria. Int J Stroke. 2008 Nov: 3(4)290-2
Adeloye D, Ezejimofor M, Auta A, Moazanje R, Ezeigwe N, Nigige .E et al. Estimating Morbidity due to stroke in Nigeria: A systematic review and meta15 Analysis. J neurol Sci 2019. (402)136-144
Akinyemi RO, Ovbiagele B, Mayowa O. Stroke in Africa: Profile, Progress, Prospects and Priorities, Nature Reviews, Neurology, 17: 634-656
Feigin VL, Brainin M, Norrving B, Martins S, Sacco Ret al. World Stroke Organization (WSO). Global Stroke Fact Sheet, 2022. Int J Stroke 2022: 17(1)18-29.
Ajidahun O.M, Bebibele C.O. Electrolyte derangements and its association with mortality in stroke patients in the University College Hospital, Ibadan, Nigeria. Afr Biomed Res, 2020. 59-63.
Wali VV, Patil SS. A comparative study of serum electrolytes and lipids in Ischemic and Hemorrhagic stroke. Int J Research Med Sci, 2016, vol 4 (II) 4838-4842.
Alemayehu E, Fasil A, Nigatie M, Ambachewb S. Serum Lipid Profile of stroke patients attending Dessie Compr ehensive Hospit a l De ssi e, Northeast. Ethopia. A Comparative Cross Sectional study Heriyon 2023 mar 9(3).
Hassan MK, Hassan MB, Rubaiyat KA. Electrolyte disturbances in Acute phase of stroke patients. Dinajpur Med Col J Jan 6 (1):12-16
Ahmad J Farooq O, Sanaie A et al. Study of Electrolyte abnormalities in Acute stroke and correlation with outcome. IJMSIR 2021. 6(1)337-338.
Setya Wati YD et al. Electrolyte disturbances and lipid profiles in Ischemic and hemorrhagic stroke patients in Aisyiyah Bojonegoro Hospital, Indonesia. Int J Res Med Sci 2020. Jun 8 (6):2028-2032
Ehtesham M Mohmand M, Raj K, Hussain T, Kavita F, Kumar B et al. Clinical Spectrum of Hyponatremia in patients with stroke. Ceureus 2019, Aug 11 (8).
Liamis G, Barkas F, Megapanou E, Christopoulou E, Makri A et al. Hyponatremia in Acute stroke patients: Pathophysiology, Clinical significance and management options. Eur Neurol (2019) 82 (1-3):32-40
Khan A, Khan z, Khan S, Ullah A, Ayub G, Tariq Net al. Frequency of hyponatremia and its impact on prognosis in ischemic stroke. Cerues 2023
Gariballa SE, Robinson TG, Fortherby MD. Hypokarlemia and potassium excretion in stroke patients. J Am Geriatric Soc 2015, 45:1454-1458.
Huang X, Zhang Y. Relationship between serum bicarbonate level and the risk of death within 30 days in ICU patients with acute ischemic stroke. Front Neurol 2023; 14:
Bei Hz You S-J, Zheng D, Zhong C-K, Du HP et al. Prognostic role of hypochloraemia in acute stroke patients. Acta Neurol Scandinavice 2017, 136.
Bharosay A, Bharosay V, Bandyopadhyay D, Sodani A, Varma M, Baruah Het al. Effect of Lipid profile upon prognosis in Ischeamic and hemorrhagic cerebrovascular stroke. India J Clin Biochem 2014.
Rehman NU, Bilal M, Shah SA, Imran M, Masood A. Frequency of deranged lipid profile in patients with stroke. Pakistan J Neurol 2023.27.4.
Mansoor F Kumar Jitesh, Kaur N, Sultan S, Tahir H et al. Frequency of electrolyte imbalance in patients presenting with acute stroke. Ceureus 2021 13(9).
Farahmand F,Choobi AB, Heshmat R, Ghafoui HB, Henedanchi S Serum sodium and potassium levels in cerebrovascular accident patients. Maleys T Med Sci 2013: 20:39-43
Kabin H, HU Y, Wu Y, Ji Z, Wang S, Lin Z, Pan S et al. Hyperchloremia is associated with poorer outcome in critically ill stroke patients. Front Neurol 2018; 9:485
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