Effect of Occupational exposure to Gasoline on Reproductive and Thyroid hormones among male Petrol station attendants in Kwara State
Keywords:BTEX, Thyroid, Petrol, testosterone
Introduction: Petrol fume contain organic compounds that have been suggested to be endocrine
disruptors. There is paucity of data on petrol fume-linked health challenges in Nigeria. Thus, we evaluated
the effects of petrol fume exposure on blood levels of reproductive and thyroid hormones among petrol
pump station attendants in Kwara state, Nigeria.
Material and Methods: Eighty (80) petrol station attendants and fifty (50) non-occupationally exposed
subjects were recruited as controls. Anthropometric indices were taken and fasting blood samples were
collected after signing the consent form. Free triiodothyronine (FT3), free thyroxine (FT4), thyroid
stimulating hormone (TSH), testosterone, follicle stimulating hormone and luteinizing hormone were
evaluated using standard techniques.
Results: Average age and BMI of petrol fume-exposed subjects are 27.40±0.419 and 24.98±0.254
respectively and was not different from controls. Elevated FT3 and FT4 were evaluated with a decreased
TSH level in the exposed group when compared with controls. In contrast, FSH, LH and testosterone
were significantly reduced in exposed group when compared with control.
Conclusion: The result of this study shows that petrol fume toxicants adversely alter thyroid and gonadal
functions thereby modulating circulating levels of reproductive and thyroid hormones in male petrol
station attendants in Kwara state.
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