Effects of Sub Chronic Exposure to Diesel Combustion Fumes on Hematological Parameters of Wister Rats
Keywords:
Sub-chronic exposure, Combustion fume, Hematological parametersAbstract
Introduction: Several studies on the health effects of diesel exhaust from conventional road and non road sources have been documented but no record of any such work done on combustion fumes from a diesel lamp.
Aim: The present study was undertaken to evaluate the effects of exposure to diesel combustion fumes from an open lamp on the haematological parameters of Wister rats.
Method: Fifteen rats were weighed and divided into 3 groups, n = 5; control rats were unexposed to diesel combustion fumes, group A and group B rats had daily (4hrs) exposure to diesel combustion fumes in an enclosed chamber with open vents for 2 and 3 weeks respectively. At the end of which they were weighed again before their hematological parameters were assessed using standard laboratory methods.
Result: The results showed a statistically significant difference in mean blood level of bicarbonate ions of 20.0±1.47mmol/Linthecontrolgroupcomparedto25.25±0.85mmol/L inratsexposedtofumesfor 3 weeks. It also showed decreases in the mean packed cell volume, blood hemoglobin concentration, total white blood cell count (relative lymphocytosis). Increased erythrocyte sedimentation rate accompanied by increasing neutrophil counts in rats in groups A and B compared with their matched controls. These changes were however not statistically significant (all P> 0.05).
Conclusion: There was no significant impact of diesel exhaust fume from the lamp on most of the hematological parameters assessed in this study.
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