Assessment Of Haematological And Antioxidants Changes In Male Albino Wistar Rats Treated With Tramadol

Authors

  • Ossai Nduka Richard HUMAN PHYSIOLOGY Author
  • Ojieh Anthony Emeka Author
  • Nwogueze Bartholomew Chukwuebuka Author

Keywords:

Tramadol, antioxidants, rat

Abstract

Abstract
Introduction
Illicit drug use disorders are a major public health burden that contributes significantly to the global burden of disease and tramadol is one of the most common illicit psychoactive substances being abused especially amongst the young adults. This research aims to assess the haematological and antioxidants activities of male wistar rats treated with tramadol.

Materials and Methods
Thirty adult male Wistar rats weighing 120-180 g were selected for the study and was randomized into 6 groups. Group 1 was not treated within the period of the study before sacrificing, Group 2 to 5 received 30 mg/kg body weight of tramadol for 7, 14, 21 and 42 days respectively while treatment for group 6 was withdrawn for 3 weeks after 21 days treatment period before sacrificing. The animal's Brain, Liver, kidney and Testis were excised for biochemical analysis. Generated data were analyzed using SPSS package and results expressed as mean ± SEM.

Results
Results obtained showed significant decrease in the haemtololgical parameters as well as in the WBC count, Catalase, SOD and Glutathione activities in the chronic tramadol-treated rats when compared to the normal control at p<0.05. This study also revealed that chronic tramadol use increases the level ofMDA significantly when compared with the non-treated group.

Conclusion
Tramadol consumption lowers RBC count, haemoglobin level, PCV, platelet count, WBC count, CAT, SOD, and GSH activities while significantly raising MDA levels. Therefore tramadol should only be used under medical supervision and only on prescription, avoiding indiscriminate and long-term.

Author Biographies

  • Ossai Nduka Richard, HUMAN PHYSIOLOGY

    Department of Human Physiology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria.

  • Ojieh Anthony Emeka

    Department of Human Physiology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria.

  • Nwogueze Bartholomew Chukwuebuka

    Department of Human Physiology, College of Health Sciences, Evangel University, Akaeze, Ebonyi State Nigeria.

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Assessment Of Haematological And Antioxidants  Changes In Male Albino Wistar Rats Treated With  Tramadol

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Published

01/01/2022

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Assessment Of Haematological And Antioxidants Changes In Male Albino Wistar Rats Treated With Tramadol. AJTMBR [Internet]. 2022 Jan. 1 [cited 2024 Jun. 18];5(2):30-42. Available from: https://ajtmbr.org.ng/index.php/home/article/view/68

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