Blood Glucose and Hepato-Renal Alterations Following Administration of Gongronemalatifolium and Allium sativum in Diabetic Wistar Rats
Gongronemalatifoliumand Allium sativummodulates diabetic hepatorenal alterations
Keywords:
Diabetes mellitus, Gongronema latifolium, Allium sativum, hypoglycaemiaAbstract
Background: Gongronema latifolium (GL) and Allium sativum (AS) are reported to possess anti-diabetic properties, and preference to its single or concomitant use varies widely.
Objective: The effect of concomitant use of (GL) leaves and (AS) bulb extracts, on the hepato-renal indices of Streptozotocin (STZ) induced hyperglycemic rats was studied.
Materials and methods: Diabetes mellitus was induced by single intraperitoneal dose of (STZ) at 65 mg per kg body weight (bwt) of rats. Thirty female Wistar rats (160 –180 g) were randomly divided into 6 groups of 5 animals each. Groups I and II received 10 mL distilled water per kg bwt and served as normal and diabetic controls [NC and DC] respectively. Group III received Metformin 150 mg per kg bwt of rat, while groups IV, V and VI received 400 mg of AS, GL, and AS + GL extracts per kg body weight respectively. Biochemical analyses were performed after the experimental period of 14 days.
Results: Body weight significantly (p < 0.05) increased in animals treated with the extracts compared to DC. Blood glucose levels, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase concentrations significantly (p < 0.05) decreased in the treatment groups, compared to DC. The concentrations of total protein, albumin, sodium, potassium and chloride were significantly increased while urea and creatinine concentrations were significantly decreased when compared to DC.
Conclusion: Extracts of AS and GL singly and in concomitantly use exhibited antihyperglycemic and hepato-renal protective properties, however combined doses outperformed single administration.
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