Hyperglycemic emergencies in a tertiary health facility

Clinical presentation and predictors of mortality

Authors

Keywords:

Hyperglycemic emergencies, Diabetes Ketoacidosis, Hyperglycemic Hyperosmolar State, mortality

Abstract

Abstract
Aim: To assess the clinical presentations and predictors of mortality of hyperglycemic emergencies (HE)
in persons with diabetes mellitus (DM) presenting in a tertiary health facility in Nigeria.

Methods: This was a two-year retrospective review of hospital records of persons with DM in a tertiary
hospital in Nigeria. We retrieved data on person’s demographics, clinical and laboratory characteristics
into Microsoft Excel and analyzed with STATA version 14.

Results: A total of 195 (42.4%) out of 460 persons admitted with DM fulfilled the eligibility criteria.
Diabetic ketoacidosis (DKA) was present in 42.6%, mixed hyperglycemic emergency (MHE) in 34.9%
and hyperglycemic hyperosmolar state (HHS) in 22.5%. Mortality in HE was 8.7%. The common clinical
presentation were: osmotic symptoms (71.3%), tachypnoea (46.7%), tachycardia (42.6%). Elevated anion
gap (89.2%) and anemia (80.5%) were the common laboratory findings. Infections (86.7%), noncompliance (79.5%) and newly diagnosed DM were the common precipitants of HE. Significant
predictors of mortality were: duration of DM between 5-9 years, Glasgow Coma Scale (GCS) < 8,
hypotension, and hypokalemia.

Conclusion: HE is still a common cause of hospitalization and mortality in persons with DM; and
features such osmotic symptoms, tachypnea and high anion gap metabolic acidosis should alert the
clinician.

Author Biographies

  • Beatrice Ohunene Bello-Ovosi

    Department of Internal Medicine, Kaduna State University/Barau Dikko Teaching

    Hospital, Kaduna, Nigeria

  • Isa Kweumpo Bansi

    National Industrial Court Clinic, Abuja, Nigeria

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Hyperglycemic emergencies in a tertiary health facility: Clinical presentation and predictors of mortality

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Published

01/01/2022

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Hyperglycemic emergencies in a tertiary health facility: Clinical presentation and predictors of mortality. AJTMBR [Internet]. 2022 Jan. 1 [cited 2024 Jul. 18];5(2):6-23. Available from: https://ajtmbr.org.ng/index.php/home/article/view/84

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